What is Retatrutide?
Retatrutide, a new medication created by the pharmaceutical company Eli Lilly, has a major potential for the treatment of obesity and diabetes. Also known as GGG Tri-agonist, GLP-1/GIP/glucagon tri-agonist, or LY3437943, this injectable medication is set for FDA approval. It is similar to existing weight loss medications like tirzepatide and semaglutide but has increased efficacy. When combined with proper diet, regular exercise, and lifestyle modifications, retatrutide can help improve weight loss outcomes and treat comorbidities related to obesity such as diabetes or hypertension (high blood pressure).
Retatrutide is more effective than other weight loss medications. It exerts its therapeutic effects through three important mechanisms:
- Gastric inhibitory polypeptide receptor (GIPR) agonist: As a GIP receptor agonist, retatrutide enhances appetite suppression and prevents fat accumulation, resulting in decreased energy intake and increased energy expenditure.
- Glucagon-like peptide 1 receptor (GLP-1R) agonist: Retatrutide reduces body weight by improving blood sugar levels via enhanced insuli release from the pancreas and reduced release of glucagon (a hormone that increases blood sugar).
- Glucagon receptor (GR) agonist: Retatrutide decreases glucagon release to improve blood sugar levels, decrease food intake, and increase energy expenditure, which ultimately results in weight loss.
BENEFITS OF GLP-1 AGONISTS
- Helps slow food leaving your stomach
- Helps prevent your liver from making too much sugar
- It helps the pancreas produce more insulin when your blood sugar levels are high
- Can help control blood glucose
- Can reduce hyperglycemia, especially after meals
- Can reduce fasting insulin and fasting glucose
- Can reduce hemoglobin A1c
- Can decrease appetite and caloric intake while inhibiting weight gain
- Has been shown to lower triglyceride levels and oxidative stress from high LDL
- Has been shown to help induce weight loss in obese patients with higher dosing
- Helps decrease leptin and increase leptin sensitivity
- Can increase the conversion of white fat to brown fat
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